Isotretinoin, a currently widely used therapy derived from vitamin A, transformed acne treatment. However, it may cause adverse effects and has. Isotretinoin (trade name: Accutane) is a powerful drug used in the treatment of acne. Four to five months of Accutane treatment usually leads to clearing of acne. Isotretinoin (Accutane) is a medication that is used to treat severe recalcitrant nodular acne when nothing else seems to work. Teens who take. You must agree in writing to use two specific forms of birth control beginning 30 days before you start taking Accutane and ending 30 days this web page you stop taking it. Severe acne can be difficult to treat. For some patients, this cure is permanent. Studies show this helps some patients see clear skin. Diminished ability to see in the dark. Dry skin. Protect your skin from the sun and do not use a tanning bed, sun lamp, or other indoor tanning device. Isotretinoin Accutane is a medication that is used to treat severe recalcitrant nodular acne when nothing else seems to work.