As albumin is a major determinant of vascular colloid oncotic pressure (COP), and reduced levels seen in critical illness may contribute to tissue edema and. A large randomized controlled trial is needed to determine if albumin plus furosemide is truly more effective than furosemide alone in critically ill. The combination of a loop diuretic (furosemide) and albumin has resulted in decrerased edema, particularly in patients with hypoalbuminemia. Akcicek F. Combination therapy resulted in a decrease in body weight, abdominal ircumference, and edema 1 and 24 h after administration. Figure 1. Greater increase in total protein in treatment group at day 3 and day 5. Diuretics like furosemide are the first choice for reducing the edema. Thus, furosemide is a drug of choice in edematous patients as indicated in acute or chronic kidney disease, congestive heart failure, hepatic cirrhosis and for patients who need natriuresis such as in hypertensive patients [ 131 — 33 ].