Furosemide is a loop diuretic (water pill) that prevents your body from cyclosporine (Neoral, Gengraf, Sandimmune);; digoxin (Lanoxin);; ethacrynic acid. People with heart failure who take digoxin are commonly given medicines called diuretics. This drugs remove excess fluid from the body. Learn about drug interactions between digoxin oral and furosemide oral and use the RxList drug interaction checker to check drug combinations. Presently, spironolactone is considered an add-on to loop diuretic therapy if patients suffer hypokalaemia or diuretic resistance [ 45 ]. Minor Minimally clinically significant. Furosemide 80 mg-ROX round, white, imprinted with 54 An ECG is done to check for irregular heartbeats. The risk was particularly high for concomitant use of digoxin with a combination of loop diuretics, thiazide and potassium-sparing diuretics. The findings of the impact of different diuretic classes in combination with digoxin on the risk of digoxin intoxication might not be generalizable. Clinicians should be vigilant in monitoring the presence of digoxin toxicity in HF patients treated with digoxin, especially when the complexity of the diuretic regimen is increased. Updated by: Michael A. Interaction between digoxin and diuretics is one of the most common drug—drug interactions DDI experienced in the clinical setting [ 12 ]. A neurohormonal modulator in heart failure? You are article source likely to have this condition if you take digoxin, digitoxin, or other digitalis medicines along with drugs that interact with it. Seek emergency medical attention or call the Poison Help line at To learn more visit Healthwise. Diuretics prescribed in the 1 week preceding the index date. Furosemide can pass into breast milk and may harm a nursing baby.