Lasix (Furosemide) is a very effective water pill and it'll certainly make you go Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't especially during the first few weeks of treatment to monitor drug level in the body . History of heart problems; Drug interactions; Wolff-Parkinson-White syndrome. Learn about drug interactions between digoxin oral and furosemide oral and use the RxList drug interaction checker to check drug combinations. Clinical and cardiovascular responses to drug therapy with furosemide were compared with those to furosemide plus digoxin in 15 heart patients with sinus. Discontinuation of escitalopram should be considered in patients who develop symptomatic hyponatremia. Loratadine; Pseudoephedrine: Moderate The cardiovascular effects link sympathomimetics may reduce the antihypertensive effects produced by diuretics. Desmopressin: Major Desmopressin, when used in the treatment of nocturia is contraindicated with loop diuretics because of the risk of severe hyponatremia. Audiologic monitoring may be advisable during high dose therapy or therapy of long duration, when hearing loss is suspected, or in selected risk groups. Contacts and Locations.