The purpose of this study was to avoid the need for dialysis by infusion of the solution of mannitol, furosemide, and dopamine in the early postoperative period in. Although furosemide and mannitol have been reported to protect against cis- dichlorodiammineplatinum(ll). (COOP)- induced nephrotoxicity, the possibility that. Mannitol and furosemide, when used together, produced a greater (% versus %) and more sustained (5 hours versus 2 hours) fall in ICP than mannitol. Neurosurgery 6: — mannito Anesthesiology 28—30, false. To add an email address to your ASA account please contact us:. Effects of acute therapy with diuretics. Exp Neurol —, false. One hour later, arterial blood gases, pH, and plasma osmolality were again measured. Differences in MAP, manjitol blood gases, and osmolality were examined using two-way repeated-measures analysis of variance with group as the between-group factor and values measured before and after drug administration as the repeated measure. Twelve injured animals died before the end of the experiment. Our goal, however, was to mimic the usual situation in the operating room, where only single doses are given and where relatively acute effects on brain swelling are of the greatest interest. Clin Neurol Neurosurg. ENW EndNote. Delete Cancel Save. No interactions were found between Lasix and mannitol. View Full Size. Therapy with a combination of mannitol and furosemide was first described by Harbaugh et al. In that study it was postulated that the enhanced reduction in ICP and the prolongation of the period of effectiveness of the combination therapy as compared to mannitol alone, was the result of an initial reversal of the blood-brain osmotic gradient with mannitol, and subsequent sustaining of this favorable gradient by the action of furosemide upon the renal tubule by preferential excretion of water over mannitol, thereby prolonging the effectiveness of a single mannitol dose. Fay T: The treatment of acute and chronic cases of cerebral trauma, by methods of dehydration. Alan Stevens Similar articles in PubMed. J Neurotrauma. Wilkinson HA, Rosenfeld S: Furosemide and mannitol in the treatment of acute experimental intracranial hypertension. It is hence possible that regional changes in furosemide-induced water consider, lasix for fluid retention with might have been missed.